In a recent episode of The Spa Dr. Podcast, Dr. Trevor Cates and her guest, Dr. Angela Mezza, a triple board-certified endocrinologist, discussed the growing interest in GLP-1 agonist medications such as Ozempic.
GLP-1 agonist medications are a type of medicine that helps control blood sugar levels and support weight loss. They work by mimicking a natural hormone in your body (GLP-1) that helps regulate appetite, slow digestion, and improve insulin function. These medications are often used to treat type 2 diabetes but are also prescribed for weight management.
As these treatments gain attention for their role in weight management, many people are curious about their benefits, potential drawbacks, and how they fit into a holistic wellness approach.
What Are GLP-1 Agonists?
Dr. Mezza explained that GLP-1 (glucagon-like peptide-1) is a hormone naturally produced in the intestine. GLP-1 agonist medications were initially developed to help regulate blood sugar levels in individuals with type 2 diabetes. The first, Exenatide (Byetta), was introduced in 2005.
“GLP-1 agonists were originally designed for those with type 2 diabetes,” Dr. Mezza explained. “But an interesting effect was observed—some patients also experienced weight loss.”
This led pharmaceutical companies to explore their role in supporting weight management.
Who May Consider These Medications?
According to Dr. Mezza, beyond individuals with type 2 diabetes, others who might consider GLP-1 agonists like Ozempic include:
- Those showing signs of insulin resistance, particularly with weight gain around the midsection
- Women in perimenopause and menopause who notice increased difficulty managing their weight
- Individuals committed to making dietary and lifestyle adjustments alongside medication
Dr. Mezza emphasized, “These medications are not a substitute for healthy habits. A patient needs to be motivated to adjust their diet and lifestyle for the best results.”
Understanding Potential Considerations
Like all medications, GLP-1 agonists (including Ozempic) are known to have potential side effects that individuals should be aware of, including:
- Temporary digestive discomfort, such as nausea or constipation
- Increased risk of pancreatitis (those with a history of pancreatitis should consult their healthcare provider)
- Risk of muscle loss if adequate protein intake is not maintained
- Hair thinning, which may be associated with significant weight changes
- Potential effects on gut motility that require monitoring
“We want to support muscle retention,” Dr. Mezza noted. “Ensuring sufficient protein intake while using these medications is essential.”
A Holistic Approach to Blood Sugar and Weight Balance
Both agreed that GLP-1 agonists should be viewed as part of a broader approach to overall well-being. Dr. Mezza shared several natural ways to encourage the body’s own GLP-1 production:
- Eating lean proteins and fiber-rich foods
- Incorporating water-rich vegetables
- Supporting gut health with certain probiotics
- Considering dietary supplements such as berberine, curcumin, and glutamine
For maintaining balanced blood sugar levels, she suggested:
- Limiting processed carbohydrates and refined grains
- Incorporating intermittent fasting strategically (with individual considerations, especially for women)
- Supporting metabolic health with nutrients such as berberine, chromium picolinate, alpha-lipoic acid, and citrus bergamot
- Focusing on gut health and fiber intake (aiming for 30 grams daily)
The Long-Term Question
One key discussion point was whether these medications should be used indefinitely.
“I don’t see these as a lifelong solution,” Dr. Mezza stated. “If lifestyle changes aren’t in place, discontinuing the medication may result in regaining weight.”
Both discussed viewing GLP-1 agonists as a temporary tool to assist in metabolism support while sustainable habits are developed.
The Role of Stress and Sleep in Weight Balance
The conversation also touched on the significant impact of stress and sleep quality, especially for women as they age.
“Stress plays a major role,” Dr. Mezza emphasized. “Elevated cortisol levels can contribute to insulin resistance, making it harder to maintain a healthy weight.”
With age-related hormonal shifts, including changes in estradiol and progesterone, a combination of stress, poor sleep, and metabolic changes can make weight management more challenging.
Proactive Health Monitoring
Dr. Mezza recommends regular lab work every six months, including:
- Fasting glucose and insulin levels
- Hemoglobin A1c
- Advanced lipid panels, including LDL particle number and small LDL
- C-reactive protein (CRP) to monitor inflammation
“The earlier you start monitoring, the better,” she advised. “Taking proactive steps now sets the foundation for long-term health.”
Exploring Natural Support Options
There are also natural ways to support your overall well-being, including lifestyle habits, dietary choices, and holistic remedies. Incorporating nutrient-rich foods, staying active, managing stress through mindfulness practices, and considering herbal supplements can all play a role in maintaining balance and promoting long-term health.
Supplements are never a substitute for medication or recommendations from your physician. However, they can complement your healthy lifestyle.
The Spa Dr. Wellness Support Formulas
The Spa Dr. Hormone Balance Blend
This wellness formula features a curated selection of natural extracts to help support overall well-being:*
- Saw palmetto
- Chaste tree berry
- Maca root
- Dong quai
- Black cohosh
Supports overall well-being in areas such as:
✔️ Helps maintain a sense of balance and comfort during mild hormonal shifts*
✔️ Supports energy and vitality*
✔️ Helps maintain mental clarity and focus*
The Spa Dr. Sleep Restore
Quality sleep is a crucial part of wellness. The Spa Dr. Sleep Restore includes:
- Vitamin B6 – Supports normal hormonal activity related to sleep*
- Magnesium – Helps promote an overall sense of wellbeing, calm and relaxation*
- Proprietary herbal blend – Includes natural ingredients commonly used to support normal, restful sleep*
Always talk to your personal physician before taking a new supplement.
| Disclaimer:
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. The views and opinions expressed by guests on this podcast and within related website content are solely their own and do not necessarily reflect the views or opinions of The Spa Dr., its employees, or affiliates or that of Dr. Cates. This podcast and its associated content are intended for informational and entertainment purposes only. The information provided during the podcast and on the website should not be construed as medical advice. Always consult with a qualified healthcare professional before making any changes to your diet, exercise regimen, or supplement usage, especially if you have any pre-existing medical conditions or are taking medications. |
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